amide bond is a bond that is commonly found in drug molecules.
why the amide bond is less susceptible to hydrolysis than the ester bond due?
my opinion :
because the amide carbonyl carbon less electrophilic (carbon to nitrogen bond diaanggap as a double bond) and the amine group as a leaving group, leaving group is weak. The drugs are like paracetamol, chloramphenicol, lincomycin, indometacin, and all known sulfacetamida amines and acids produced by hydrolysis reaction.
how about your opinion?
please, comment ^_^ 
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